Genetic study of Lewy's body dementia

 Genetic study of Lewy's body dementia supports ties to Alzheimer's and Parkinson's diseases. 


"Lewy's physical dementia is a devastating brain disorder for which we have no effective treatment. Patients often appear to suffer the most from Alzheimer's and Parkinson's diseases. Our findings support the notion that leukemia is caused by a spectrum of physical dementia. NIH's National Institute of Neurological Disorders and Stroke (NINDS) and research. 

"We hope these issues can be addressed in both issues," said Sanjay Saloos, senior author of the research, PhD, MD, PhD, MD, PhD, MD. These findings will serve as a blueprint for understanding the disease and developing new treatments. "The research was led by Dr. Skills' team and researchers in the lab of Brian J. Trainor, MD, PhD. Was a senior investigator at the NIH's National Institute on Aging (NIA). Affects people over 5 years old. Early symptoms of the disease include laughter, mood swings, and problems with thinking, movement, and sleep. Initially, cognitive and behavioral patients are usually diagnosed with dementia, but sometimes Alzheimer's disease is also mistakenly identified. 

Alternatively, many patients who are initially diagnosed with Parkinson's may eventually experience thinking and mood disorders caused by Levi's physical dementia. In both cases, as the disease progresses, the patient becomes severely disabled and may die within 8 years of diagnosis. 

The growing body of evidence suggests that genetics may play a role in the disorder and that some cases may be inherited. Scientists have found that mutations in the genes for alpha cynocline (SNCA), a key protein found in leukemia, can lead to some of these rare cases.

 Further studies have shown that different types of genes for apoliprotein E (APOE), which are known to play a role in Alzheimer's disease, may also play a role in leukemia. 

"Compared to other neurodegenerative disorders, Levi has very little information about the genetic forces behind physical dementia," 

said Dr. Trainor. 

"To get a better understanding, we wanted to study the genetic architecture of Liu's physical dementia." 

To do so, they compared the chromosomal DNA sequences of 2,981 Levi's physical dementia patients with 4,931 healthy, age-controlled participants. Samples were collected from participants of European descent at 44 sites: 17 in Europe and 27 in North America. 

The DNA sequence was led by Clifton Dalgard, PhD, and researchers at the American Genome Center, a series of state-of-the-art laboratories at the Uniform Services University of Health Sciences, supported by Henry M. Jackson. 

Foundation for the Advancement of Military Medicine. Initially, they found that the sequence of five genes from patients with leukemia dementia often differed from these controls, suggesting that these genes may be important. This was the first time that two genes, BIN1 and TMEM175, had been infected. 

These genes may also be linked to Alzheimer's and Parkinson's diseases. The other three genes, SNCA, APOE, and GBA, were involved in previous studies, and thus, the importance of the gene in leukemia dementia was strengthened. 

The researchers also looked at differences in the same five genes when they compared the DNA sequences of 970 Levi's physical dementia patients with a new set of 8,928 control subjects, confirming their preliminary results. Further analysis suggests that changes in the activity of these genes may lead to dementia and that the GBA gene may have a particularly strong effect on the disease. 

The gene encods the guidelines for beta-glucosilceramides, a protein that helps the cell's recycling system break down sugary fats. Are 

"These results provide a list of five genes that we suspect levy plays a role in physical dementia,"

 said Dr Trainor. Finally, to examine the clear link between leukemia and other neurological disorders, researchers further analyzed data from previous studies on Alzheimer's and Parkinson's disease. 

They found that patients' genetic profiles were more likely to develop Alzheimer's or Parkinson's disease than age-controlled subjects. These predictions came after they downplayed the potential effects of genes that cause Alzheimer's and Parkinson's disease, such as APOE and SNCA. Interestingly, Parkinson's disease, on the one hand, and Parkinson's disease, on the other, were not associated with the genetic risk characteristics of Alzheimer's disease. Dr. Schulz said, "Although Alzheimer's and Parkinson's disease have very different moral and medical disorders,

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